- serine/threonine kinase
- STK
- WNK
- DCLK
- GCN
- GAK
- SRPK
- PASK
- BUB1
WNK 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S8358 | WNK463 | WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM. | Selective | WNK1, IC50: 5nM; WNK2, IC50: 1nM; WNK3, IC50: 6nM; WNK4, IC50: 9nM |
| S0015 | WNK-IN-11 | WNK-IN-11 is a potent, selective, and orally acitve allosteric inhibitor of With-No-Lysine (WNK) kinase with IC50 of 4 nM for WNK1 enzyme. | Selective | WNK1, IC50: 4 nM |
