S1950 |
Metformin HCl
|
Metformin HCl (1,1-Dimethylbiguanide HCl)降低肝细胞中高血糖症,主要通过抑制肝糖原的产生(肝脏糖异生作用)发挥作用。Metformin可促进单核细胞中的线粒体自噬。Metformin可通过激活JNK/p38 MAPK 信号通路和GAD153来诱导肺癌细胞系的凋亡。 |
-
Nat Commun, 2024, 15(1):1785
-
J Clin Invest, 2024, e175023
-
EBioMedicine, 2024, 102:105090
|
|
S4701 |
2-DG (2-Deoxy-D-glucose)
|
2-DG (2-Deoxy-D-glucose), 一种葡萄糖类似物,是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。 |
-
EMBO Mol Med, 2024, 10.1038/s44321-024-00136-9
-
Int J Biol Sci, 2024, 20(3):848-863
-
Int J Biol Macromol, 2024, 280(Pt 4):135580
|
|
S2610 |
Lonidamine
|
Lonidamine是一种口服的小分子己糖激酶抑制剂,IC50为0.85 mM。 |
-
Cancer Lett, 2024, 589:216824
-
Mol Oncol, 2023, 17(9):1821-1843
-
Mol Oncol, 2023, 17(9):1821-1843
|
|
S5426 |
Bromopyruvic acid (3-BP)
|
Bromopyruvic acid (3-BP)是一种己糖激酶II抑制剂,对糖酵解/己糖激酶的Ki值为2.4mM。它是肿瘤细胞能量代谢的抑制剂和铂类药物的化疗增敏剂。 |
-
iScience, 2024, 27(3):109246
-
Cancer Sci, 2024, 10.1111/cas.16204
-
EMBO Rep, 2023, e56325.
|
|
S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂,IC50为72 nM。 |
-
Cell Rep Med, 2023, 4(6):101056
-
Cell Rep Med, 2023, 4(6):101056
-
Free Radic Biol Med, 2021, 163:220-233
|
|
S2155 |
LY2608204
|
LY2608204 可以激活葡萄糖激酶(GK), EC50 为 42 nM。Phase 2。 |
-
Sci Rep, 2017, 7:44681
-
Nat Commun, 2016, 7:11463
|
|
S1271 |
Acarbose
|
Acarbose(BAY g 5421,Prandase, Precose, Glucobay, Bay-g 5421) 是一种肠道alpha-glucosidase抑制剂,用于治疗II型糖尿病。 |
-
Infect Genet Evol, 2020, 81:104210
|
|
S3300 |
Desoxyrhaponticin
|
Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。 |
-
Nat Metab, 2021, 10.1038/s42255-021-00479-4
|
|
S3839 |
1-Deoxynojirimycin
|
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
-
J Biol Chem, 2022, 298(12):102643
|
|
S6921 |
Dorzagliatin
|
Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) 是一种双效的 glucokinase (GK) 的激活剂,可改善2型糖尿病患者的血糖控制和胰腺β细胞功能。 |
-
Proc Natl Acad Sci U S A, 2022, 119(31):e2204407119
|
|
S3918 |
4',7-Dimethoxy-5-Hydroxyflavone
|
4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells. |
-
Nat Cell Biol, 2022, 24(3):364-372
|
|
S4101 |
Voglibose
|
Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物,对α葡糖苷酶具有优异的抑制活性,也具有抗高血糖症和由高血糖症引起的各种疾病的作用。
|
-
G3 (Bethesda), 2020, 4;10(5):1585-1597
|
|
F0435New |
Hexokinase I Rabbit mAb
|
|
|
|
S3278 |
Kaempferol-3-O-neohesperidoside
|
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮,通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis。 |
|
|
S3245 |
Nodakenetin
|
Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素,可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达,并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。 |
|
|
E1353 |
AZD1656
|
AZD1656 是一种有效的、选择性的、口服活性的葡萄糖激酶激活剂。 AZD1656具有用于2型糖尿病研究的潜力。 |
|
|
S2589 |
Miglitol
|
Miglitol是一种口服抗糖尿病药物。 |
|
|
E0477 |
N-Caffeoyl O-methyltyramine
|
N-Caffeoyl O-methyltyramine是从Cuscuta reflexa中分离得到的一种生物碱,对α-葡萄糖苷酶(α-glucosidase)具有较强的抑制活性,IC50为103.58 μM。 |
|
|
E3072 |
Paniculata Extract
|
Paniculata Extract是从中药布渣叶(Microcos paniculata L.)中提取的,具有多种生物学功能,包括抗氧化活性和α-葡萄糖苷酶抑制作用。 |
|
|
S3243 |
Zeaxanthin
|
Zeaxanthin是一种类胡萝卜素醇,参与叶黄素循环,激活外在凋亡途径,诱导葡萄膜黑色素瘤细胞凋亡,IC50 值为40.8 µM。 |
|
|
E2846 |
FBPase-1 inhibitor-1
|
FBPase-1 inhibitor-1是一种果糖-1,6-二磷酸酶(fructose-1,6-bisphosphatase, FBPase-1)的变构抑制剂,在MG和耦合格式,这两种不同的FBPase-1活性测定中表现出相似的效力,IC50分别为3.4 μM和4.0 μM。 |
|
|
S0553 |
Butyl isobutyl phthalate
|
Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的,α-glucosidase 的非竞争性抑制剂,其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。 |
|
|
E3107 |
Andrographis Herba Extract
|
Andrographis Herba Extract提取自穿心莲Andrographis paniculata (Burm. F.) Nees的地上部分,具有多种活性,包括抗菌和抗氧化,抗疟疾,抗血管生成,抗炎,抗糖尿病,和体外α-葡萄糖苷酶和α-淀粉酶抑制活性。 |
|
|
S3527 |
AM2394
|
AM-2394是一种结构独特的葡萄糖激酶激活剂(glucokinase activator, GKA),可激活葡萄糖激酶(glucokinase , GK),EC50为60 nM。 |
|
|
E3333 |
Viburnum Dilatatum Extract
|
Viburnum Dilatatatum Extract从荚蒾Viburnum Dilatatatum中提取,具有α-葡萄糖苷酶抑制活性和降血糖作用。 |
|
|
S0808 |
Ketohexokinase inhibitor 1
|
Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) 是一种有效的酮己糖激酶 (ketohexokinase, KHK) 抑制剂,对 KHK-C 和 KHK-A 的 IC50 分别为 8.4 nM 和 66 nM。 |
|
|
E2509 |
WAY-297848
|
WAY-297848 是一种新型葡萄糖激酶(glucokinase)激活剂,具有预防或治疗高血糖、糖尿病、肥胖症、血脂异常、代谢综合征等应用前景。 |
|
|
F0230New |
Insulin Receptor β Rabbit mAb
|
Insulin Receptor β Rabbit mAb recognizes endogenous levels of total Insulin Receptor β protein. |
|
|
F2476New |
FBP1 Rabbit mAb
|
|
|
|
S9378 |
4',5-Dihydroxyflavone
|
4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase. |
|
|
S3796 |
Rebaudioside A
|
Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. |
|
|
S2949 |
KPLH1130
|
KPLH1130 是丙酮酸脱氢酶激酶(pyruvate dehydrogenase kinase, PDK)的特异性抑制剂,可阻断巨噬细胞极化并减弱促炎反应。 |
|
|
F1626New |
Anti-PGK1 Rabbit mAb
|
|
-
Cell Death Dis, 2024, 15(4):267.
|
|
S4793 |
Cedryl acetate
|
Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
|
|
E4014 |
4-Nitrophenyl alpha-D-glucopyranoside
|
4-Nitrophenyl alpha-D-glucopyranoside是 α-葡萄糖苷酶抑制测定中的显色底物。 |
|
|
S5426 |
Bromopyruvic acid (3-BP)
|
Bromopyruvic acid (3-BP)是一种己糖激酶II抑制剂,对糖酵解/己糖激酶的Ki值为2.4mM。它是肿瘤细胞能量代谢的抑制剂和铂类药物的化疗增敏剂。 |
- iScience, 2024, 27(3):109246
- Cancer Sci, 2024, 10.1111/cas.16204
- EMBO Rep, 2023, e56325.
|
|
S3300 |
Desoxyrhaponticin
|
Desoxyrhaponticin (DC, DES) 是一种来自中国传统的营养食品 Rheum tanguticum Maxim. ex Balf. (rhubarb) 的对称二苯代乙烯配糖体,是 fatty acid synthase (FAS/FASN) 的抑制剂。Desoxyrhaponticin (DC, DES) 也是竞争性的 glucose 摄取的抑制剂,在兔肠膜囊泡和大鼠肠翻肠中的IC50值分别为148.3 μM和30.9 μM。Desoxyrhaponticin 对人癌细胞具有凋亡作用。 |
- Nat Metab, 2021, 10.1038/s42255-021-00479-4
|
|
S3918 |
4',7-Dimethoxy-5-Hydroxyflavone
|
4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells. |
- Nat Cell Biol, 2022, 24(3):364-372
|
|
S4101 |
Voglibose
|
Voglibose (AO 128) 是一种N取代的井岗霉醇胺衍生物,对α葡糖苷酶具有优异的抑制活性,也具有抗高血糖症和由高血糖症引起的各种疾病的作用。
|
- G3 (Bethesda), 2020, 4;10(5):1585-1597
|
|
S3245 |
Nodakenetin
|
Nodakenetin (NANI) 是从Angelica decursiva中分离出的植物性香豆素,可抑制 α-glucosidase、PTP1B、rat lens aldose reductase (RLAR)、AChE、BChE 和 β-site amyloid precursor protein cleaving enzyme 1 (BACE1)。Nodakenetin 可改变 Bax 和 Bcl-2 的蛋白质表达,并促进线粒体凋亡。Nodakenetin 具有抗肿瘤活性。 |
|
|
S2589 |
Miglitol
|
Miglitol是一种口服抗糖尿病药物。 |
|
|
E0477 |
N-Caffeoyl O-methyltyramine
|
N-Caffeoyl O-methyltyramine是从Cuscuta reflexa中分离得到的一种生物碱,对α-葡萄糖苷酶(α-glucosidase)具有较强的抑制活性,IC50为103.58 μM。 |
|
|
E3072 |
Paniculata Extract
|
Paniculata Extract是从中药布渣叶(Microcos paniculata L.)中提取的,具有多种生物学功能,包括抗氧化活性和α-葡萄糖苷酶抑制作用。 |
|
|
S3243 |
Zeaxanthin
|
Zeaxanthin是一种类胡萝卜素醇,参与叶黄素循环,激活外在凋亡途径,诱导葡萄膜黑色素瘤细胞凋亡,IC50 值为40.8 µM。 |
|
|
E2846 |
FBPase-1 inhibitor-1
|
FBPase-1 inhibitor-1是一种果糖-1,6-二磷酸酶(fructose-1,6-bisphosphatase, FBPase-1)的变构抑制剂,在MG和耦合格式,这两种不同的FBPase-1活性测定中表现出相似的效力,IC50分别为3.4 μM和4.0 μM。 |
|
|
S0553 |
Butyl isobutyl phthalate
|
Butyl isobutyl phthalate (BIP) 是一种从 Laminaria japonica 的根状茎中分离出来的,α-glucosidase 的非竞争性抑制剂,其IC50值为38 μM。Butyl isobutyl phthalate 具有显著的降血糖作用和治疗糖尿病的潜力。 |
|
|
E3107 |
Andrographis Herba Extract
|
Andrographis Herba Extract提取自穿心莲Andrographis paniculata (Burm. F.) Nees的地上部分,具有多种活性,包括抗菌和抗氧化,抗疟疾,抗血管生成,抗炎,抗糖尿病,和体外α-葡萄糖苷酶和α-淀粉酶抑制活性。 |
|
|
E3333 |
Viburnum Dilatatum Extract
|
Viburnum Dilatatatum Extract从荚蒾Viburnum Dilatatatum中提取,具有α-葡萄糖苷酶抑制活性和降血糖作用。 |
|
|
S0808 |
Ketohexokinase inhibitor 1
|
Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) 是一种有效的酮己糖激酶 (ketohexokinase, KHK) 抑制剂,对 KHK-C 和 KHK-A 的 IC50 分别为 8.4 nM 和 66 nM。 |
|
|
S9378 |
4',5-Dihydroxyflavone
|
4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase. |
|
|
S3796 |
Rebaudioside A
|
Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), an natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. |
|
|
S2949 |
KPLH1130
|
KPLH1130 是丙酮酸脱氢酶激酶(pyruvate dehydrogenase kinase, PDK)的特异性抑制剂,可阻断巨噬细胞极化并减弱促炎反应。 |
|
|
S4793 |
Cedryl acetate
|
Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity. |
|
|
S4701 |
2-DG (2-Deoxy-D-glucose)
|
2-DG (2-Deoxy-D-glucose), 一种葡萄糖类似物,是具有抗病毒活性的糖酵解抑制剂。2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。 |
- EMBO Mol Med, 2024, 10.1038/s44321-024-00136-9
- Int J Biol Sci, 2024, 20(3):848-863
- Int J Biol Macromol, 2024, 280(Pt 4):135580
|
|
S2610 |
Lonidamine
|
Lonidamine是一种口服的小分子己糖激酶抑制剂,IC50为0.85 mM。 |
- Cancer Lett, 2024, 589:216824
- Mol Oncol, 2023, 17(9):1821-1843
- Mol Oncol, 2023, 17(9):1821-1843
|
|
S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂,IC50为72 nM。 |
- Cell Rep Med, 2023, 4(6):101056
- Cell Rep Med, 2023, 4(6):101056
- Free Radic Biol Med, 2021, 163:220-233
|
|
S2155 |
LY2608204
|
LY2608204 可以激活葡萄糖激酶(GK), EC50 为 42 nM。Phase 2。 |
- Sci Rep, 2017, 7:44681
- Nat Commun, 2016, 7:11463
|
|
S3839 |
1-Deoxynojirimycin
|
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus. |
- J Biol Chem, 2022, 298(12):102643
|
|
S3278 |
Kaempferol-3-O-neohesperidoside
|
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种从Primula latifolia Lapeyr. 和 Primula vulgaris Hudson 的叶提取物中分离出的类黄酮,通过 PI3K - GSK-3 信号通路和 MAPK - PP1 通路来刺激大鼠比目鱼肌中的糖原合成 glycogen synthesis。 |
|
|