Atorvastatin

中文名称:阿托伐他汀

Atorvastatin 是一种降脂剂。 它是 hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 的竞争性抑制剂,它可通过甲羟戊酸途径生物合成胆固醇的速率决定酶并激活自噬。

Atorvastatin Chemical Structure

Atorvastatin Chemical Structure

CAS: 134523-00-5

规格 价格 库存 购买数量
10mM (1mL in DMSO) 810.81 现货
25mg 795.31 现货
100mg 1613.43 现货
1g 7125.48 现货
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Atorvastatin相关产品

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
hepatocytes Function assay 0.1 to 10 uM up to 90 mins Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method, Km=0.43μM 22593038
hepatocytes Function assay 0.1 to 10 uM up to 90 mins Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay, Km=1.3μM 22593038
Hep3G Function assay 25 uM 48 hrs Inhibition of HMG CoA reductase in human Hep3G cells assessed as increase in LDL receptor expression at 25 uM incubated for 48 hrs by immunofluorescence method 31005367
C2C12 Function assay 1 uM Induction of cell differentiation in mouse C2C12 cells assessed as myosin heavy chain expression at 1 uM 20081855
HepG2 Function assay 1 uM Upregulation of LDL receptor expression in human HepG2 cells at 1 uM in presence of ARH-specific siRNA 20356098
HepG2 Function assay 10 uM Induction of SREBP2 maturation in human HepG2 cells at 10 uM after overnight incubation by immunoblot analysis 26784936
A549 Cytotoxicity assay 72 hrs Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=8.7μM 23570542
HS68 Cytotoxicity assay 72 hrs Cytotoxicity against human HS68 cells after 72 hrs by MTT assay, IC50=22.7μM 23570542
MEF Cytotoxicity assay 72 hrs Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay, IC50=30.7μM 23570542
human red blood cells Antiplasmodial assay 48 hrs Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells after 48 hrs by SYBR test, IC50=10.3μM 26988303
HEK293 Function assay TP_TRANSPORTER: uptake in OATP1B1-expressing HEK293 cells, Km=12.4μM 15970799
L6 Function assay Inhibition of cholesterol synthesis in rat L6 cells assessed as incorporation of [14C]acetate into cholesterol, IC50=0.078μM 18412317
HEK293 Function assay Activity at human liver OATP1B3 expressed in HEK293 Flp-In cells, Km=0.73μM 22541068
HEK293 Function assay Activity at human liver OATP1B1 expressed in HEK293 Flp-In cells, Km=0.77μM 22541068
HEK293 Function assay Activity at human liver OATP2B1 expressed in HEK293 Flp-In cells, Km=2.84μM 22541068
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estradiol-17beta-glucuronide substrate, IC50=0.6μM 22587986
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using pitavastatin substrate, IC50=0.8μM 22587986
HEK293 Function assay Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estrone-3-sulfate substrate, IC50=1.6μM 22587986
A549 Function assay Reductase Activity Assay: The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lysates from A549 cells. Lovastatin was used as a positive control, and SAHA as a negati, IC50=0.0116μM ChEMBL
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生物活性

产品描述 Atorvastatin 是一种降脂剂。 它是 hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 的竞争性抑制剂,它可通过甲羟戊酸途径生物合成胆固醇的速率决定酶并激活自噬。

化学信息&溶解度

分子量 558.64 分子式

C33H35FN2O5

CAS号 134523-00-5 SDF --
Smiles CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
储存条件(自收到货起) 3年 -20°C 粉状

体外溶解度
批次:

DMSO : 100 mg/mL ( (179.0 mM) ;DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Ethanol : 17 mg/mL (30.43 mM)

Water : Insoluble

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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