Tauroursodeoxycholic Acid (TUDCA)

中文名称:牛磺熊去氧胆酸

Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物,在多种神经退行性疾病,如阿尔茨海默病、帕金森疾病和亨廷顿疾病中,可作为线粒体稳定剂和抗凋亡试剂。

Tauroursodeoxycholic Acid (TUDCA) Chemical Structure

Tauroursodeoxycholic Acid (TUDCA) Chemical Structure

CAS: 14605-22-2

规格 价格 库存 购买数量
10mM (1mL in DMSO) 1203.93 现货
25mg 1040.45 现货
1g 7944.3 现货
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Tauroursodeoxycholic Acid (TUDCA)相关产品

细胞实验数据示例

细胞系 实验类型 给药浓度 孵育时间 活性描述 文献信息
HuH7 Cytoprotective assay 1 mM 24 hrs Cytoprotective activity against DCA-induced cell death in human HuH7 cells assessed as increase in cell viability at 1 mM preincubated with cells followed by DCA addition measured after 24 hrs by MTT/INCELL assay 27729186
HEK293 Function assay 90 mins Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay, IC50=10.3μM 28165241
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of CHOP mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as increase in XBPu mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against DCA-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of XBPs mRNA levels after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as reduction in XBPs/XBPu ratio after 6 hrs 27729186
HuH7 Cytoprotective assay 6 hrs Cytoprotective activity against tunicamycin-induced ER stress in human HuH7 cells assessed as inhibition of BIP/GRP78 mRNA levels after 6 hrs 27729186
CHO cells Function assay Agonist activity at human TGR5 expressed in CHO cells by luciferase assay, EC50=30 μM 18307294
Sf9 Function assay TP_TRANSPORTER: uptake in membrane vesicles from Bsep-expressing Sf9 cells, Km=4.1μM 10648470
MDCK Function assay TP_TRANSPORTER: uptake in Oatp3-expressing MDCK cells, Km=6.6μM 11093941
Sf9 Function assay TP_TRANSPORTER: uptake in membrane vesicles isolated from Bsep-expressing Sf9 cells, Km=11.9μM 12404240
CHO Function assay TP_TRANSPORTER: uptake in Ntcp-expressing CHO cells, Km=14μM 9486191
COS Function assay TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells, Ki=28μM 9458785
HEK293 Function assay Non-competitive inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in LPC hydrolysis by Lineweaver-Burk plot analysis 28165241
点击查看更多细胞系数据

生物活性

产品描述 Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物,在多种神经退行性疾病,如阿尔茨海默病、帕金森疾病和亨廷顿疾病中,可作为线粒体稳定剂和抗凋亡试剂。
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05753852 Recruiting
Amyotrophic Lateral Sclerosis
Humanitas Mirasole SpA|University of Ulm|University of Sheffield|University Hospital Tours|KU Leuven|UMC Utrecht|University of Dublin Trinity College|Bruschettini S.r.l.|Istituto Superiore di Sanità|Motor Neurone Disease Association
October 25 2021 Phase 3
NCT04114292 Unknown status
Ulcerative Colitis
Washington University School of Medicine|Crohn''s and Colitis Foundation
January 17 2019 Phase 1
NCT01899703 Completed
Cholestasis Intrahepatic
GlaxoSmithKline
March 10 2014 Phase 2

化学信息&溶解度

分子量 499.70 分子式

C26H45NO6S

CAS号 14605-22-2 SDF Download Tauroursodeoxycholic Acid (TUDCA) SDF
Smiles CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
储存条件(自收到货起)

体外溶解度
批次:

DMSO : 100 mg/mL ( (200.12 mM) ;DMSO吸湿会降低化合物溶解度,请使用新开封DMSO)

Water : 100 mg/mL (200.12 mM)

Ethanol : 50 mg/mL (100.06 mM)

摩尔浓度计算器

体内溶解度
批次:

现配现用,请按从左到右的顺序依次添加,澄清后再加入下一溶剂

动物体内配方计算器

实验计算

摩尔浓度计算器

质量 浓度 体积 分子量

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

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