RUNX

亚型特异性产品

RUNX2

RUNX产品

所有产品(7)
RUNX抑制剂 (3)
RUNX激活剂 (4)
新RUNX产品

目录号	产品名	产品描述	文献引用	实验数据
S0790	CADD522	CADD522 是一种有效的 RUNX2(runt-related transcription factor-2)-DNA 结合的抑制剂，对应的IC50值为10 nM。CADD522 具有抗肿瘤的活性。	Sci Rep, 2025, 15(1):6832 bioRxiv, 2025, 2025.07.21.665972
S9709	Muramyl dipeptide (MDP)	Muramyl dipeptide (MDP) 是肽聚糖的共有结构单元。Muramyl dipeptide 通过诱导 Runx2 来诱导 bone formation。	Frontiers in Cell and Developmental Biology, August 20, 2021, 707959 Oxid Med Cell Longev, 2021, 2021:2353504 Frontiers in Cell and Developmental Biology, 2021, 707959
E2692	L-Ascorbic acid 2-phosphate sesquimagnesium salt	L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium)是一种长效维生素C衍生物，能刺激胶原蛋白的形成和表达，可作为人脂肪干细胞(human adipose stem cells, hASCs)成骨分化的培养基补充，提高hASCs成骨分化过程中碱性磷酸酶(alkaline phosphatase, ALP)的活性和runx2A的表达。	J Funct Biomater, 2024, 15(12)385
S3223	L-Quebrachitol	L-Quebrachitol (L-QCT) 是可从许多植物中分离出来的天然产物，促进增殖和细胞DNA合成。L-Quebrachitol 可上调 bone morphogenetic protein-2 (BMP-2)、runt-related transcription factor-2 (Runx2) 和 mitogen-activated protein kinase (MAPK) 相关调控基因和 Wnt/β-catenin 信号通路，同时下调 nuclear factor-κB(NF-κB) 配体 (RANKL) 受体激活剂的mRNA水平。
E2909	L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate	L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate 是一种维生素C衍生物。 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate 在 hASCs 的成骨分化过程中增加碱性磷酸酶 (ALP) 活性和 runx2A 的表达。
S8756	XRK3F2	XRK3F2是p62-ZZ抑制剂，在体外钝化多发性骨髓瘤（MM）诱导的Runx2抑制作用，在体内肿瘤存在的情况下，诱导新骨形成和重塑。
E8328^New	Ro24-7429	Ro24-7429 is a benzodiazepine derivative that acts as a potent, orally active antagonist of HIV-1's Tat transactivator protein, disrupting viral replication by inhibiting Tat-mediated transactivation of the HIV-1 long terminal repeat (LTR) promoter. It also inhibits RUNX1 (runt-related transcription factor 1), contributing to antifibrotic effects by reducing fibrosis markers in models like bleomycin-induced pulmonary fibrosis, alongside anti-inflammatory properties.
S0790	CADD522	CADD522 是一种有效的 RUNX2(runt-related transcription factor-2)-DNA 结合的抑制剂，对应的IC50值为10 nM。CADD522 具有抗肿瘤的活性。	Sci Rep, 2025, 15(1):6832 bioRxiv, 2025, 2025.07.21.665972
S8756	XRK3F2	XRK3F2是p62-ZZ抑制剂，在体外钝化多发性骨髓瘤（MM）诱导的Runx2抑制作用，在体内肿瘤存在的情况下，诱导新骨形成和重塑。
E8328^New	Ro24-7429	Ro24-7429 is a benzodiazepine derivative that acts as a potent, orally active antagonist of HIV-1's Tat transactivator protein, disrupting viral replication by inhibiting Tat-mediated transactivation of the HIV-1 long terminal repeat (LTR) promoter. It also inhibits RUNX1 (runt-related transcription factor 1), contributing to antifibrotic effects by reducing fibrosis markers in models like bleomycin-induced pulmonary fibrosis, alongside anti-inflammatory properties.
S9709	Muramyl dipeptide (MDP)	Muramyl dipeptide (MDP) 是肽聚糖的共有结构单元。Muramyl dipeptide 通过诱导 Runx2 来诱导 bone formation。	Frontiers in Cell and Developmental Biology, August 20, 2021, 707959 Oxid Med Cell Longev, 2021, 2021:2353504 Frontiers in Cell and Developmental Biology, 2021, 707959
E2692	L-Ascorbic acid 2-phosphate sesquimagnesium salt	L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium)是一种长效维生素C衍生物，能刺激胶原蛋白的形成和表达，可作为人脂肪干细胞(human adipose stem cells, hASCs)成骨分化的培养基补充，提高hASCs成骨分化过程中碱性磷酸酶(alkaline phosphatase, ALP)的活性和runx2A的表达。	J Funct Biomater, 2024, 15(12)385
S3223	L-Quebrachitol	L-Quebrachitol (L-QCT) 是可从许多植物中分离出来的天然产物，促进增殖和细胞DNA合成。L-Quebrachitol 可上调 bone morphogenetic protein-2 (BMP-2)、runt-related transcription factor-2 (Runx2) 和 mitogen-activated protein kinase (MAPK) 相关调控基因和 Wnt/β-catenin 信号通路，同时下调 nuclear factor-κB(NF-κB) 配体 (RANKL) 受体激活剂的mRNA水平。
E2909	L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate	L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate 是一种维生素C衍生物。 L-Ascorbic acid 2-phosphate sesquimagnesium salt hydrate 在 hASCs 的成骨分化过程中增加碱性磷酸酶 (ALP) 活性和 runx2A 的表达。
E8328^New	Ro24-7429	Ro24-7429 is a benzodiazepine derivative that acts as a potent, orally active antagonist of HIV-1's Tat transactivator protein, disrupting viral replication by inhibiting Tat-mediated transactivation of the HIV-1 long terminal repeat (LTR) promoter. It also inhibits RUNX1 (runt-related transcription factor 1), contributing to antifibrotic effects by reducing fibrosis markers in models like bleomycin-induced pulmonary fibrosis, alongside anti-inflammatory properties.