- ACAT
- ACAT1
- ACAT2
- DGAT
- DGAT1
- DGAT2
ACAT 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S0820 | RP-64477 | RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively. | Selective | ACAT, IC50: 113 nM; ACAT, IC50: 503 nM; ACAT, IC50: 180 nM |
| S2187 | Avasimibe | Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively. | Selective | ACAT, IC50: 3.3 μM |
| S4189 | Cyclandelate | Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM. | Selective | ACAT, IC50: 80 μM |
