| S8220 |
INCB3344 |
INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. |
Selective |
hCCR2, IC50: 5.1 nM |
| S8361 |
PF-4136309 |
PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2. |
Selective |
CCR2, IC50: 5.2 nM |
| S9738 |
RS504393 |
RS504393, an extremely selective CC chemokine receptor (CCR) 2 antagonist with IC50 of 98 nM, also targets multiple receptors for inhibition of CCR2b and CCR1 receptors when administrated in higher concentration. |
Selective |
CCR2, IC50: 98 nM |
| S7538 |
RS-102895 Hydrochloride |
RS-102895 hydrochloride (HCl) is a potent antagonist of Chemokine (C-C motif) receptor 2 (CCR2) with IC50 of 360 nM, and shows no effect on CCR1. RS-102895 hydrochloride also inhibits human α1a and α1d receptors, rat brain cortex 5-HT1a receptor in cells with IC50s of 130 nM, 320 nM, 470 nM, respectively. |
Selective |
CCR2, IC50: 360 nM |
| S3383 |
RS102895 |
RS 102895 is a small molecule antagonist of CCR2 with an IC50 of 360 nM. |
Selective |
CCR2, IC50: 360 nM |
| S8512 |
Cenicriviroc |
Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity. |
Pan |
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| S0085 |
BMS-813160 |
BMS-813160 is a potent, well-absorbed dual CCR2 and CCR5 chemokine antagonist. BMS-813160 inhibits inflammatory processes, angiogenesis, tumor cell migration, tumor cell proliferation and invasion. |
Pan |
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