CDK13 选择性抑制剂
| 目录号 |
产品名 |
产品描述 |
Selective / Pan |
IC50 / Ki |
| S8894 |
SR-4835 |
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors. |
Selective |
CDK13, IC50: 4.9 nM |
| S6595 |
THZ531 |
THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. |
Pan |
CDK13, IC50: 69 nM |
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