- Cathepsin
- Calpain
- Cruzain
- Papainb
- Cathepsin
Calpain 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S7424 | PD 151746 | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. | Selective | μ-Calpain, IC50: 260 nM; m-calpain, IC50: 5.33 μM |
| S7394 | MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase. | Selective | |
| S7396 | Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells. | Pan | Calpain I (porcine erythrocytes), ID50: 52 nM; Calpain II (porcine kidney), ID50: 34 nM; Calpain I (human platelets), ID50: 40 nM |
