| S0194 |
Balicatib |
Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K. |
Selective |
|
| S4591 |
Nitroxoline |
Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. Nitroxoline impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity. |
Selective |
|
| S7420 |
CA-074 methyl ester (CA-074 Me) |
CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
Selective |
|
| S1115 |
Odanacatib |
Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3. |
Selective |
Cathepsin K (human), IC50: 0.2 nM; Cathepsin K (rabbit), IC50: 1 nM |
| S5611 |
2-cyano-Pyrimidine |
2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. |
Selective |
Cathepsin K, IC50: 170 nM |
| S7381 |
Pepstatin A |
Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. |
Selective |
|
| S2847 |
Cathepsin Inhibitor 1 |
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
Pan |
Cathepsin L, pIC50: 7.9; Cathepsin L2, pIC50: 6.7; Cathepsin S, pIC50: 6; Cathepsin K, pIC50: 5.5; Cathepsin B, pIC50: 5.2 |
