- EGFR/ErbB1
- HER2/ErbB2
- ErbB3
- ErbB4
- mutant EGFR
ErbB3 抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S2192 | Sapitinib (AZD8931) | Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2. | Pan | ErbB3, IC50: 4 nM |
