Hedgehog
Smoothened
GLI

GLI 选择性抑制剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S6565	JK184	JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells.	Selective
S8075	GANT61	GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells.	Selective	GLI1, IC50: 5 μM