- MAP4K2
- MAP4K4
- MAP4K6
- MAP4K7
MAP4K4 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S6499 | PF-6260933 | PF-6260933 (PF-06260933) is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. | Selective | MAP4K4, IC50: 3.7 nM |
| S0268 | DMX-5084 | DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. | Pan | human MAP4K4, IC50: 3 nM; human MAP4K4, pIC50: 8.55 |
