MNK1
MNK2

MNK2 抑制剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S8275	Tomivosertib (eFT-508)	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.	Pan	MNK2, IC50: 1 nM
S6888	SEL201	SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 nM and 5.4 nM, respectively.	Pan	MNK2, IC50: 5.4 nM
S6658	ETC-206 (AUM 001)	ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.	Pan	MNK2, IC50: 86 nM