NUDIX1 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S7631 | TH287 | TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. | Selective | MTH1, IC50: 0.8 nM |
| S7632 | TH588 | TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM. | Selective | MTH1, IC50: 5 nM |
| S7505 | (S)-crizotinib | (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay. | Selective | MTH1, IC50: 72 nM |
