PDE1
PDE2
PDE3
PDE4
PDE5
PDE6
PDE10A
PDE9
PDE4B

PDE4B 抑制剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S2620	GSK256066	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.	Pan	PDE4B, IC50: 3.2 pM
S1430	Rolipram (ZK-62711)	The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.	Pan	PDE4B, IC50: 130 nM