- PGD1
- PGD2
- PGE2
- PGE4
- PGF2α
- PGI2
- TXA2
- TXB2
PGD2 选择性拮抗剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S0495 | BI-671800 | BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS. | Selective | human CRTH2, IC50: 4.5 nM; murine CRTH2, IC50: 3.7 nM |
