- PGD1
- PGD2
- PGE2
- PGE4
- PGF2α
- PGI2
- TXA2
- TXB2
PGE4 选择性抑制剂 | 拮抗剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S6649 | E7046 (ER-886406) | E7046 (ER-886406, Palupiprant, AN0025) is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM. | Selective | EP4, IC50: 13.5nM; EP4, Ki: 23.14 nM |
| S6694 | Grapiprant (CJ-023,423) | Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively. | Pan | EP4, IC50: 35 nM; EP4, Ki: 24 nM; rat EP4 receptor, Ki: 20 nM; human EP4 receptor, Ki: 13 nM |
