- PGD1
- PGD2
- PGE2
- PGE4
- PGF2α
- PGI2
- TXA2
- TXB2
PGI2 选择性激动剂 | 拮抗剂 | 调节剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S3346 | 1-Methylnicotinamide chloride | 1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation. |
Selective | |
| S0305 | RO1138452 | RO1138452 (CAY10441) is a potent and selective antagonist of IP (prostacyclin, PGI2) receptor with pKi of 9.3 and 8.7 in human platelets and a recombinant IP receptor system, respectively. | Selective | PGI2, pKi: 9.3; PGI2, pKi: 8.7 |
| S0325 | Treprostinil sodium | Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively. | Pan | IP, Ki: 32 nM |
