PLK1
PLK2
PLK3
PLK4

PLK3 抑制剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S1109	BI 2536	BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.	Pan	PLK3, IC50: 9.0 nM
S2880	GW843682X	GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ~30 other kinases.	Pan	PLK3, IC50: 9.1 nM