| S0174 |
TRPM8 antagonist 2 |
TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes. |
Selective |
TRPM8, IC50: 0.2 nM |
| S6638 |
AMG-333 |
AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8. |
Selective |
rat TRPM8, IC50: 30 nM |
| S2963 |
WS-12 |
WS-12 is a potent TRPM8 agonist with an EC50 of 39 nM. |
Selective |
TRPM8, EC50: 39 nM |
| S6122 |
Cyclohexanecarboxamide |
Cyclohexanecarboxamide (Ethyl menthane carboxamide, WS3, Hexahydrobenzamide) is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM). |
Selective |
TRPM8, EC50: 3.7 μM |
| S6070 |
CBA (TRPM4-IN-5) |
CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM. |
Selective |
TRPM4, IC50: 1.5µM |
