| S1180 |
XAV-939 |
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. |
Pan |
TNKS2, IC50: 4 nM |
| S7238 |
NVP-TNKS656 |
NVP-TNKS656 is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM for TNKS2, > 300-fold selectivity against PARP1 and PARP2.
|
Pan |
TNKS2, IC50: 6 nM |
| S8876 |
RK-287107 |
RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM. |
Pan |
Tankyrase-2, IC50: 10.6 nM |
| S7490 |
WIKI4 |
WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
|
Pan |
TNKS2, IC50: 15 nM |
| S7239 |
G007-LK |
G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively.
|
Pan |
TNKS2, IC50: 25 nM |
| S6739 |
MN 64 |
MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively. |
Pan |
TNKS2, IC50: 72 nM |
