| S0009 |
Asimadoline hydrochloride |
Asimadoline hydrochloride (EMD-61753 hydrochloride) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). |
Selective |
guinea pig κ-opioid, IC50: 5.6 nM; recombined human κ-opioid, IC50: 1.2 nM |
| S2322 |
(+)-Matrine |
Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. |
Selective |
|
| S5935 |
Alvimopan |
Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
κ-opioid receptor, Ki: 40 nM |
| S5701 |
Alvimopan dihydrate (LY246736 dihydrate) |
Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
κ-opioid receptor, Ki: 40 nM |
