- NMDA receptor
- AMPA receptor
- mGluR2
- mGluR3
- mGluR4
- mGluR5
mGluR4 选择性激动剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S8035 | VU 0364439 | VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. | Selective | mGluR4, EC50: 19.8 nM |
| S2892 | VU 0361737 | VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS. | Selective | mGluR4 (Human), EC50: 240 nM; mGluR4 (Rat ), EC50: 110 nM |
| S2862 | VU 0364770 | VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. | Selective | mGlu4, EC50: 1.1 μM |
