| S7310 |
SF1670
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SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。
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Oncol Rep, 2025, 54(4)125
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Nat Biomed Eng, 2024, 10.1038/s41551-024-01273-9
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J Biol Chem, 2024, S0021-9258(24)01808-8
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| S8651 |
bpV (HOpic)
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bpV (HOpic) (Bisperoxovanadium (HOpic))是一种有效的PTEN抑制剂，IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。 |
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Brain Behav Immun, 2025, 130:106111
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Cell Death Dis, 2025, 16(1):226
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Stem Cell Res Ther, 2025, 16(1):455
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| S8174 |
VO-Ohpic trihydrate
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VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂，IC50为35 nM。 |
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Cell Commun Signal, 2025, 23(1):431
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Cell Communication and Signaling, 2025, 431
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Nature, 2024, 170-178
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| S9190 |
Oroxin B
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Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment. |
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Environ Pollut, 2023, 323:121306
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Theranostics, 2022, 12(2):910-928
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J Cancer, 2021, 12(7):2140-2150
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| S0918 |
Ginkgolic acid C17:1
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Ginkgolic acid C17:1 (GAC 17:1) 通过废除上游的 JAK2 和 Src 来抑制 STAT3 的组成性激活。Ginkgolic acid C17:1 可以诱导 PTEN 和 SHP-1 的大量表达。Ginkgolic acid C17:1 诱导肿瘤细胞凋亡。 |
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| S9190 |
Oroxin B
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Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment. |
- Environ Pollut, 2023, 323:121306
- Theranostics, 2022, 12(2):910-928
- J Cancer, 2021, 12(7):2140-2150
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| S0918 |
Ginkgolic acid C17:1
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Ginkgolic acid C17:1 (GAC 17:1) 通过废除上游的 JAK2 和 Src 来抑制 STAT3 的组成性激活。Ginkgolic acid C17:1 可以诱导 PTEN 和 SHP-1 的大量表达。Ginkgolic acid C17:1 诱导肿瘤细胞凋亡。 |
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