| S4694 |
Alosetron Hydrochloride |
Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. |
Selective |
|
| S5052 |
Granisetron |
Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy. |
Selective |
|
| S2865 |
VUF 10166 |
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
Selective |
5-HT3A, Ki: 0.04 nM; 5-HT3AB, Ki: 22 nM |
| S3723 |
Ramosetron Hydrochloride |
Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity. |
Selective |
5-HT3 receptor, Ki: 0.091 nM |
| S5740 |
Palonosetron |
Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). |
Selective |
5-HT3 receptor, Ki: 0.17 nM |
| S2106 |
Azasetron HCl |
Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. |
Selective |
5-HT3, IC50: 0.33 nM |
| S5538 |
Tropisetron |
Tropisetron (ICS 205-930) is a 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor. |
Selective |
5-HT3 receptor, Ki: 5.3 nM |
| S2644 |
Lerisetron |
Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM. |
Selective |
5-HT3 receptor, IC50: 0.81 μM |
| S4748 |
Ondansetron Hydrochloride Dihydrate |
Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors. |
Selective |
5-HT3 receptor, IC50: 810 nM |
| S2578 |
1-Phenylbiguanide |
1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM. |
Selective |
5-HT3 receptor, EC50: 3.0 μM |
| S1898 |
Tropisetron HCl |
Tropisetron HCl (ICS 205-930) is a potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist, used to treat nausea and vomiting following chemotherapy. |
Selective |
|
| S1345 |
Granisetron HCl |
Granisetron is a serotonin 5-HT3 receptor antagonist,used to treat chemotherapy-induced nausea and vomiting. |
Selective |
|
| S3050 |
Palonosetron HCl |
Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
Selective |
|
| S1996 |
Ondansetron |
Ondansetron (GR 38032F, GR-C507/75,SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
Selective |
|
| S1390 |
Ondansetron HCl |
Ondansetron HCl is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. |
Selective |
|
