| S1058 |
BI-1347 |
BI-1347 is a small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM. |
Selective |
CDK8, IC50: 1.1 nM |
| S8387 |
MSC2530818 |
MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. |
Selective |
CDK8, IC50: 2.6 nM |
| S0771 |
BRD6989 |
BRD6989 is a selective inhibitor of CDK8 and CDK19. BRD6989 upregulates IL-10. BRD6989 is an analog of the natural product cortistatin A (dCA). |
Pan |
|
| S8903 |
AS2863619 |
AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells. |
Pan |
CDK8, IC50: 0.6099 nM |
| S8840 |
SEL120 (SEL120-34A) hydrochloride |
SEL120 (SEL120-34, SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively. |
Pan |
CDK8, IC50: 4.4 nM |
| S7511 |
LY2857785 |
LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9(IC50=0.011 μM) and also inhibits other transcription kinases CDK8(IC50=0.016 μM) and CDK7 (IC50=0.246 μM). |
Pan |
CDK8, IC50: 0.016 μM |
| S8520 |
Senexin A |
Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively. |
Pan |
CDK8, Kd: 0.83 μM |
| S7981 |
CCT251545 |
CCT251545 is a potent, orally bioavailable inhibitor of WNT signaling with IC50 of 5 nM in 7dF3 cells. CCT251545 also act as a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. |
Pan |
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