| S7320 |
TG003 |
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. |
Selective |
mCLK1, IC50: 20 nM; mCLK2, IC50: 200 nM; mCLK4, IC50: 15 nM |
| S7509 |
ML167 |
ML167 (CID 44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. |
Selective |
CLK4, IC50: 136 nM; CLK1, IC50: 1522 nM; CLK2, IC50: 1648 nM; Dyrk1B , IC50: 4420 nM |
