| S1123 |
Abiraterone |
Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor. |
Selective |
CYP17, IC50: 2 nM |
| S2246 |
Abiraterone Acetate |
Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor. |
Selective |
CYP17, IC50: 72 nM |
| S2803 |
Galeterone |
Galeterone (TOK-001) is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2. |
Selective |
CYP17, IC50: 300 nM |
| S6594 |
Liarozole dihydrochloride |
Liarozole Dihydrochloride is identified as a modest inhibitor of P450 with IC50 of 2.2–6.0 μM and 260 nM for CYP26 and rat CYP17 respectively. |
Pan |
CYP17, IC50: 260nM |
