| S2695 |
Nepicastat (SYN-117) HCl |
Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. |
Selective |
Bovine dopamine-beta-hydroxylase, IC50: 8.5 nM; Human dopamine-beta-hydroxylase, IC50: 9 nM |
| S4926 |
(R)-Nepicastat HCl |
(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
Selective |
Bovine dopamine-beta-hydroxylase, IC50: 25.1 nM; Human dopamine-beta-hydroxylase, IC50: 18.3 nM |
| S3273 |
Hypericin |
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
Selective |
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