AC
EPAC1
EPAC2
PACAP receptor

EPAC2 选择性抑制剂 | 拮抗剂

目录号	产品名	产品描述	Selective / Pan	IC50 / Ki
S7500	HJC0350	HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.	Selective	EPAC2, IC50: 0.3 μM
S3382	ESI-05	ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.	Selective	EPAC2, IC50: 0.43 μM
S7499	ESI-09	ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.	Pan	EPAC2, IC50: 1.4 μM
S0837	HJC0197	HJC0197 is a selective Epac 1/2 dual antagonists with an IC50 of 5.9 μM for Epac2.	Pan