| S6492 |
Doravirine (MK-1439) |
Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
Selective |
WT HIV-1 RT, IC50: 12 nM; K103N HIV-1 RT, IC50: 9.7 nM; Y181C HIV-1 RT, IC50: 9.7 nM |
| S2914 |
Dapivirine (TMC120) |
Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
Selective |
HIV reverse transcriptase, IC50: 24 nM |
| S6452 |
Delavirdine mesylate |
Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. |
Selective |
HIV1 RT, IC50: 0.26 μM |
| S3165 |
Abacavir sulfate |
Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
Selective |
|
| S1400 |
Tenofovir (GS 1278) Disoproxil Fumarate |
Tenofovir Disoproxil Fumarate (Tenofovir DF,GS-1278 Disoproxil Fumarate) belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination. |
Selective |
|
| S1719 |
Zalcitabine |
Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
Selective |
|
