- MEK1
- MEK1/2
- MEK2
- MEK5
MEK1/2 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S2134 | AZD8330 | AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. | Selective | MEK1/2, IC50: 7 nM |
| S1475 | Pimasertib (AS-703026) | Pimasertib (AS-703026, MSC1936369B, SAR 245509) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 2. | Selective | MEK1/2 (MM cell line), IC50: 5 nM-2 μM |
| S1568 | PD318088 | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | Selective |
