- PDE1
- PDE2
- PDE3
- PDE4
- PDE5
- PDE6
- PDE10A
- PDE9
- PDE4B
PDE9 选择性抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S0039 | BI-409306 | BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents. | Selective | human PDE9A, IC50: 65 nM; rat PDE9A, IC50: 168 nM |
