| S6793 |
TG4-155 |
TG4-155 is a potent and selective Prostaglandin Receptor EP2(PTGER2) antagonist with Ki value of 9.9 nM. |
Selective |
PTGER2, Ki: 9.9 nM |
| S0111 |
Taprenepag |
Taprenepag(CP-544326) is a potent and selective prostaglandin EP2 agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. |
Selective |
human EP2, IC50: 10 nM; rat EP2, IC50: 15 nM |
| S7211 |
PF-04418948 |
PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1.
|
Selective |
EP₂ receptor, IC50: 16 nM |
| S0325 |
Treprostinil sodium |
Treprostinil sodium (UT-15, Remodulin, Orenitram, Tyvaso, Trevyent) is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively. |
Pan |
EP2, Ki: 3.6 nM |
| S6694 |
Grapiprant (CJ-023,423) |
Grapiprant (CJ-023,423, AT-001, AAT-007, RQ-00000007, CJ-23423) is a novel selective EP4 Prostaglandin Receptor inhibitor with Ki of 20 nM and 13 nM for rat EP4 receptor and human EP4 receptor, respectively. |
Pan |
rat EP4 receptor, Ki: 20 nM; human EP4 receptor, Ki: 13 nM |
| S0541 |
Dazoxiben hydrochloride |
Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production. |
Pan |
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