| S0069 |
VTX-27 |
VTX-27 (Compound 27) is a potent and selective inhibitor of protein kinase C θ (PKC θ) with Ki of 0.08 nM and 16 nM for PKC θ and PKC δ, respectively. |
Selective |
PKCθ, Ki: 0.08 nM |
| S6577 |
PKC-theta inhibitor |
PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM. |
Selective |
PKCθ, IC50: 18 nM |
| S2791 |
Sotrastaurin (AEB071) |
Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM in a cell-free assay; inactive to PKCζ. Phase 2. |
Pan |
PKCθ, Ki: 0.22 nM |
| S1113 |
GSK690693 |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. |
Pan |
PKCθ, IC50: 2 nM |
