| S0855 |
TC-E 5003 |
TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound. |
Selective |
PRMT1, IC50: 1.5 μM |
| S7884 |
AMI-1 |
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
|
Selective |
human PRMT1, IC50: 8.8 μM |
| S6737 |
C7280948 |
C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro. |
Selective |
PRMT1, IC50: 12.8 μM |
| S5445 |
AMI-1 (free acid) |
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. |
Selective |
|
| S8858 |
GSK3368715 3HCl |
GSK3368715 3HCl is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. |
Pan |
|
| S8112 |
MS023 |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.
|
Pan |
PRMT1, IC50: 30 nM |
| S7820 |
EPZ020411 2HCl |
EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM. |
Pan |
PRMT1, IC50: 119 nM |
