TGFβRII 选择性抑制剂
| 目录号 |
产品名 |
产品描述 |
Selective / Pan |
IC50 / Ki |
| S6807 |
TA-02 |
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. |
Selective |
|
| S2704 |
LY2109761 |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis. |
Pan |
TβRII, Ki: 300 nM |
| S2805 |
LY364947 |
LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II. |
Pan |
TGFβRII, IC50: 0.4 μM |
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