| S0078 |
1V209 (TLR7 agonist T7) |
1V209 (T7, TLR7 agonist T7) is an agonist of Toll-like receptor 7 (TLR7) with anti-tumor effects. 1V209 can be used as vaccine adjuvants, enhances antigen specific humoral and cellular immune responses. |
Selective |
|
| S0494 |
SM 324405 |
SM 324405 (compound 9e) is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 50 nM. |
Selective |
TLR7, EC50: 50 nM |
| S7221 |
Vesatolimod (GS-9620) |
Vesatolimod (GS-9620) is a potent and selective orally active small molecule agonist of Toll-like receptor 7. |
Selective |
|
| S0716 |
E6446 |
E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. |
Pan |
|
| S9931 |
Enpatoran Hydrochloride |
Enpatoran (M5049) hydrochloride is a potent, orally active, and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. |
Pan |
TLR7, IC50: 11.1 nM |
| S9623 |
Telratolimod |
Telratolimod (3M-052, MEDI9197) is an agonist of toll-like receptor 7 (TLR-7) and toll-like receptor 8 (TLR-8) with antitumor activity. |
Pan |
|
| S8133 |
Resiquimod (R-848) |
Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2. |
Pan |
|
| S4157 |
Chloroquine diphosphate |
Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs). |
Pan |
|
