| S4787 |
Methyl syringate |
Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist. |
Selective |
|
| S3763 |
Cinnamaldehyde |
Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist. |
Selective |
|
| S3942 |
Cardamonin |
Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel. |
Selective |
hTRPA1, IC50: 454 nM |
| S3867 |
(E)-Cardamonin |
(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor. |
Selective |
TRPA1, IC50: 454 nM |
| S8073 |
Optovin |
Optovin is a reversible photoactivated TRPA1 activator.
|
Selective |
|
| S2918 |
HC-030031 |
HC-030031 (TOSLAB 829227) is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
Selective |
|
| S7848 |
QX-314 chloride |
QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels. |
Pan |
|
| S3756 |
Methyl salicylate |
Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1. |
Pan |
|
