| S8967 |
XL177A |
XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34 nM. |
Selective |
USP7, IC50: 0.34 nM |
| S6878 |
GSK2643943A |
GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho. |
Selective |
USP20/Ub-Rho, IC50: 160 nM |
| S2913 |
BAY 11-7082 |
BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells. |
Selective |
USP7, IC50: 0.19 μM; USP21, IC50: 0.96 μM; USP6, IC50: 1.7 μM |
| S7888 |
Spautin-1 |
Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis. |
Selective |
USP10, IC50: 0.5779 μM; USP13, IC50: 0.6916 μM |
| S6933 |
GEN-6776 |
GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively. |
Selective |
full length USP7, IC50: 1.34 μM; USP7 catalytic domain, IC50: 0.61 μM |
| S8904 |
USP25/28 inhibitor AZ1 |
AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively. |
Selective |
USP25, IC50: 0.62 μM; USP28, IC50: 0.7 μM |
| S6748 |
ML364 |
ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. |
Selective |
USP2, IC50: 1.1 μM; USP8, IC50: 0.95 μM |
| S7132 |
P5091 |
P5091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47. |
Selective |
USP7, EC50: 4.2 μM; USP47, IC50: 4.3 μM |
| S7134 |
IU1 |
IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy. |
Selective |
USP14, IC50: 4.7 μM |
| S7133 |
P22077 |
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47. |
Selective |
USP7, IC50: 8.6 μM; USP47, EC50: 8.74 μM |
| S6883 |
HBX 19818 |
HBX19818 is a specific inhibitor of USP7 with an IC 50 of 28.1 μM. |
Selective |
USP7, IC50: 28.1 μM |
| S4922 |
NSC 632839 |
NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively. |
Selective |
USP2, EC50: 45 μM; USP7, EC50: 37 μM |
| S6943 |
IU1-47 |
IU1-47 is a potent and specific inhibitor of USP14 with an IC50 of 0.6 μM. IU1-47 shows ∼33-fold selectivity for USP14 over USP5 (IsoT). |
Selective |
|
| S6877 |
EOAI3402143 |
EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice. |
Selective |
|
| S7130 |
PR-619 |
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy. |
Pan |
USP2 core, EC50: 7.20 μM; USP4, EC50: 3.93 μM; USP5, EC50: 8.61 μM; USP7, EC50: 6.86 μM; USP8, EC50: 4.90 μM; USP15, EC50: 8.23 μM; USP20, EC50: 5.10 μM; USP28, EC50: 6.24 μM; USP47, EC50: 8.87 μM |
| S4920 |
b-AP15 |
b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. |
Pan |
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