| S5935 |
Alvimopan |
Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
δ-opioid receptor, IC50: 4.4 nM; δ-opioid receptor, Ki: 4.4 nM |
| S5701 |
Alvimopan dihydrate (LY246736 dihydrate) |
Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. |
Pan |
δ-opioid receptor, Ki: 4.4 nM |
| S2480 |
Loperamide HCl |
Loperamide HCl (ADL 2-1294,R-18553 hydrochloride) is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. |
Pan |
δ-opioid receptor, Ki: 48 nM |
