| S2861 |
CTEP (RO4956371) |
CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors. |
Selective |
mGlu5, IC50: 2.2 nM |
| S1970 |
VU-29 |
VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor, with EC50 of 9 nM and Ki=244 nM for rat mGluR5, which is selective for mGluR5 relative to other mGluR subtypes. |
Selective |
rat mGluR5, EC50: 9 nM; rat mGluR5, Ki: 244 nM |
| S2795 |
VU 0357121 |
VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
Selective |
mGluR5, EC50: 30 nM |
| S2809 |
MPEP |
MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. |
Selective |
mGluR5, IC50: 36 nM |
| S2690 |
ADX-47273 |
ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes. |
Selective |
mGlu5, EC50: 0.17 μM |
| S2645 |
SIB 1757 |
SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8. |
Selective |
mGluR5, IC50: 0.4 μM |
