SAG (Smoothened Agonist)
SAG (Smoothened Agonist)是 Smoothened (Smo) 的有效激动剂。Smoothened Agonist 在 Shh-LIGHT2 细胞中诱导萤火虫荧光素酶表达，EC50 为 3 nM。
SAG (Smoothened Agonist) Chemical Structure
CAS: 912545-86-9
产品质控
批次：
纯度：
99.94%
99.94
SAG (Smoothened Agonist)相关产品
相关信号通路图
生物活性
| 产品描述 | SAG (Smoothened Agonist)是 Smoothened (Smo) 的有效激动剂。Smoothened Agonist 在 Shh-LIGHT2 细胞中诱导萤火虫荧光素酶表达，EC50 为 3 nM。 | ||
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| 靶点 |
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| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05937178 | Recruiting | Hepatitis B Chronic |
Huashan Hospital|The First Affiliated Hospital of Anhui Medical University|Anhui Provincial Hospital|Beijing YouAn Hospital|Peking University People''s Hospital|Peking University First Hospital|Xiamen Hospital of Traditional Chinese Medicine|First Affiliated Hospital of Fujian Medical University|LanZhou University|Third Affiliated Hospital Sun Yat-Sen University|First Affiliated Hospital of Guangxi Medical University|The Affiliated Hospital Of Guizhou Medical University|Hainan General Hospital|Hebei Medical University Third Hospital|The First Affiliated Hospital of Henan University of Traditional Chinese Medicine|Henan Provincial People''s Hospital|The Second Affiliated Hospital of Harbin Medical University|Tongji Hospital|Wuhan Union Hospital China|Renmin Hospital of Wuhan University|Central South University|Xiangya Hospital of Central South University|The First Hospital of Jilin University|the Second Hospital of Nangjing|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School|The First Affiliated Hospital with Nanjing Medical University|The Affiliated Hospital of Xuzhou Medical University|The First Affiliated Hospital of Nanchang University|Shengjing Hospital|Qingdao Sixth People''s Hospital|Shandong Provincial Hospital|The Second Hospital of Shandong University|The First Affiliated Hospital of Shanxi Medical University|Tang-Du Hospital|First Affiliated Hospital Xi''an Jiaotong University|Ruijin Hospital|West China Hospital|Tianjin Second People''s Hospital|First Affiliated Hospital of Xinjiang Medical University|The First People''s Hospital of Yunnan|Shulan (Hangzhou) Hospital|Zhejiang University|Southwest Hospital China|The Second Affiliated Hospital of Chongqing Medical University|Sichuan Provincial People''s Hospital |
January 31 2023 | -- |
| NCT05701592 | Recruiting | Posterior Cruciate Ligament Tear |
Konrad Malinowski MD|Artromedical Konrad Malinowski Clinic |
December 20 2022 | -- |
| NCT03645044 | Active not recruiting | Hiv|HBV Coinfection |
University of Melbourne|National Health and Medical Research Council Australia|The University of Western Australia|University of Adelaide|The HIV Netherlands Australia Thailand Research Collaboration|University of Malaya|YR Gaitonde Centre for AIDS Research and Education|Melbourne Health |
May 24 2018 | -- |
化学信息&溶解度
| 分子量 | 490.06 | 分子式 | C28H28ClN3OS |
| CAS号 | 912545-86-9 | SDF | -- |
| Smiles | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(Cl)C5=CC=CC=C5S4 | ||
| 储存条件(自收到货起) | 3年 -20°C 粉状 | ||
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体外溶解度 |
DMSO : 98 mg/mL ( (199.97 mM) ；DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Ethanol : 98 mg/mL (199.97 mM) Water : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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