| S1202 |
Dutasteride
|
Dutasteride (GI198745, GG-745)是5α-还原酶抑制剂。 |
-
Chemical and Pharmaceutical Bulletin, 2025, 857-867
-
Neoplasia, 2024, 101045
-
Neoplasia, 2024, 57:101045
|
|
| S2404 |
Isoliquiritigenin
|
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
-
Proceedings of the National Academy of Sciences, October 16 2018, E9869-E9878
-
The American Journal of Chinese Medicine, November 04 2023, 2221-2241
-
J Nutr Biochem, 2024, 136:109808
|
|
| S1197 |
Finasteride
|
Finasteride (MK-906)是一种类固醇II型5α-还原酶抑制剂。 |
-
PLoS One, June 2, 2016, e0156549
-
Frontiers in Pharmacology, February 20, 2023, 1038039
-
Biochem Pharmacol, 2025, 241:117171
|
|
| S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 |
-
Cell Rep Med, 2023, 4(6):101056
-
Free Radic Biol Med, 2021, 163:220-233
-
J Agric Food Chem, 2020, 68(42):11747-11757
|
|
| S9170 |
Engeletin
|
Engeletin (Dihydrokaempferol 3-rhamnoside), a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. engeletin againsts LPS-stimulated endometritis in mice via negative regulation of pro-inflammatory mediators via the TLR4-regulated NF-κB pathway. |
-
Journal of Inflammation Research, October 10, 2022, 5767-5783
-
Journal of Inflammation Research, 2022, 5767-5783
-
J Inflamm Res, 2022, 15:5767-5783
|
|
| S5803 |
Alrestatin
|
Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 |
-
iScience, 2022, 25(4):104153
|
|
| S5910 |
Alpha-Estradiol
|
Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化，是生理上几乎无活性的激素17β-雌二醇（17β- E2）的立体异构体，是雌激素 estrogen 的弱抑制剂。 |
-
Biomater Res, 2024, 28:0010
|
|
| E7600 |
Exisulind
|
Exisulind 是非甾体抗炎药 sulindac 的非活性代谢产物。Exisulind 在体外抑制醛糖还原酶，IC50 为 367 nM，并可能有助于 sulindac 对 2 型糖尿病并发症的改善作用。 |
|
|
| S3818 |
Tectoridin
|
Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy. |
|
|
| E7260 |
Tolrestat
|
Tolrestat 是一种有效的，可口服的 aldose reductase 抑制剂，IC50 值为 35 nM。 |
|
|
| S1074 |
Poliumoside
|
Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 |
|
|
| S5446 |
2-Chloro-1-(4-fluorobenzyl)benzimidazole
|
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. |
|
|
| E7937 |
Fidarestat
|
Fidarestat (SNK 860) 是一种醛糖还原酶 (aldose reductase) 抑制剂，对 aldose reductase，AKR1B10 和 V301L AKR1B10 的 IC50 值分别为 26 nM，33 μM 和 1.8 μM。Fidarestat (SNK 860) 具有研究糖尿病的潜力。 |
|
|
| S9103 |
Ginsenoside Ro
|
Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects. |
|
|
| E5720 |
Isocurcumenol
|
Isocurcumenol 可从 Curcuma zedoaria Rhizomes 中分离得到，是 ERα 的抑制剂。具有抗肿瘤活性。其对 DLA 和 KB 癌细胞的 IC50 分别为 99.1 μg/mL 和 178.2 μg/mL。 |
|
|
| S1202 |
Dutasteride
|
Dutasteride (GI198745, GG-745)是5α-还原酶抑制剂。 |
- Chemical and Pharmaceutical Bulletin, 2025, 857-867
- Neoplasia, 2024, 101045
- Neoplasia, 2024, 57:101045
|
|
| S2404 |
Isoliquiritigenin
|
Isoliquiritigenin 是Glycyrrhiza glabra根系分泌的一种类黄酮，能抑制醛糖还原酶，IC50为320 nM。具有抗肿瘤活性。 |
- Proceedings of the National Academy of Sciences, October 16 2018, E9869-E9878
- The American Journal of Chinese Medicine, November 04 2023, 2221-2241
- J Nutr Biochem, 2024, 136:109808
|
|
| S1197 |
Finasteride
|
Finasteride (MK-906)是一种类固醇II型5α-还原酶抑制剂。 |
- PLoS One, June 2, 2016, e0156549
- Frontiers in Pharmacology, February 20, 2023, 1038039
- Biochem Pharmacol, 2025, 241:117171
|
|
| S2035 |
Epalrestat
|
Epalrestat是一种醛糖还原酶 aldose reductase抑制剂，IC50为72 nM。 |
- Cell Rep Med, 2023, 4(6):101056
- Free Radic Biol Med, 2021, 163:220-233
- J Agric Food Chem, 2020, 68(42):11747-11757
|
|
| S9170 |
Engeletin
|
Engeletin (Dihydrokaempferol 3-rhamnoside), a bioactive flavonoid, has multiple biological activities such as anti-diabetic and anti-inflammatory effects. engeletin againsts LPS-stimulated endometritis in mice via negative regulation of pro-inflammatory mediators via the TLR4-regulated NF-κB pathway. |
- Journal of Inflammation Research, October 10, 2022, 5767-5783
- Journal of Inflammation Research, 2022, 5767-5783
- J Inflamm Res, 2022, 15:5767-5783
|
|
| S5803 |
Alrestatin
|
Alrestatin是aldose reductase (醛糖还原酶)抑制剂。醛糖还原酶参与了糖尿病并发症，包括糖尿病神经病变的发病机理。 |
- iScience, 2022, 25(4):104153
|
|
| S5910 |
Alpha-Estradiol
|
Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2) 是一种天然的、非雌性化，是生理上几乎无活性的激素17β-雌二醇（17β- E2）的立体异构体，是雌激素 estrogen 的弱抑制剂。 |
- Biomater Res, 2024, 28:0010
|
|
| E7260 |
Tolrestat
|
Tolrestat 是一种有效的，可口服的 aldose reductase 抑制剂，IC50 值为 35 nM。 |
|
|
| S1074 |
Poliumoside
|
Poliumoside对于晚期糖基化终产物的形成有显著抑制作用，IC50值为19.69 µM。 在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside对rat lens aldose reductase(RLAR)表现出抑制作用，IC50值为8.47 µM。 |
|
|
| S5446 |
2-Chloro-1-(4-fluorobenzyl)benzimidazole
|
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. |
|
|
| E7937 |
Fidarestat
|
Fidarestat (SNK 860) 是一种醛糖还原酶 (aldose reductase) 抑制剂，对 aldose reductase，AKR1B10 和 V301L AKR1B10 的 IC50 值分别为 26 nM，33 μM 和 1.8 μM。Fidarestat (SNK 860) 具有研究糖尿病的潜力。 |
|
|
| E5720 |
Isocurcumenol
|
Isocurcumenol 可从 Curcuma zedoaria Rhizomes 中分离得到，是 ERα 的抑制剂。具有抗肿瘤活性。其对 DLA 和 KB 癌细胞的 IC50 分别为 99.1 μg/mL 和 178.2 μg/mL。 |
|
|
