- CXCR1
- CXCR2
- CXCR4
- CXCR3
CXCR4 选择性抑制剂 | 激动剂 | 拮抗剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S0292 | MSX-127 | MSX-127 (NSC-23026) is a C-X-C chemokine receptor type 4 (CXCR4) receptor antagonist. | Selective | |
| S3951 | Tannic acid | Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity. | Selective | |
| S0293 | MSX-130 | MSX-130 is an antagonist of C-X-C chemokine receptor type 4 (CXCR4). | Selective | |
| S9725 | Balixafortide (POL6326) | Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist. |
Selective | |
| S8505 | LY2510924 | LY2510924 is a potent and selective CXCR4 antagonist that specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nmol/L and inhibits SDF-1-induced GTP binding with Kb value of 0.38 nmol/L. | Selective | CXCR4, IC50: 0.079 nM |
| S2912 | WZ811 | WZ811 is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM. | Selective | CXCR4, EC50: 0.3 nM |
| S9665 | Motixafortide (BL-8040) | Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. | Selective | CXCR4, IC50: 1 nM |
| S6617 | MSX-122 | MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM). | Selective | CXCR4, IC50: ~10 nM |
| S8030 | Plerixafor (AMD3100) | Plerixafor (AMD3100, JM 3100, SID791) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor inhibits human immunodeficiency virus (HIV) replication. | Selective | CXCR4, IC50: 44 nM |
| S3013 | Plerixafor (AMD3100) 8HCl | Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent. | Selective | CXCR4, IC50: 44 nM |
| S8309 | ATI-2341 | ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. | Selective | CXCR4, EC50: 194 nM |
| S2879 | AMD3465 hexahydrobromide | AMD3465 is a monomacrocyclic CXCR4 antagonist. | Selective | |
| S8813 | LIT-927 | LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma. | Selective |
