| S8934 |
VTP50469 |
VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
Selective |
Menin-MLL interaction, Ki: 104 pM |
| S8934 |
VTP50469 |
VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity. |
Selective |
Menin-MLL interaction, Ki: 104 pM |
| S7817 |
MI-503 |
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
Selective |
Menin-MLL interaction, IC50: 14.7 nM |
| S7817 |
MI-503 |
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. |
Selective |
Menin-MLL interaction, IC50: 14.7 nM |
| S7816 |
MI-463 |
MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
Selective |
Menin-MLL interaction, IC50: 15.3 nM |
| S7816 |
MI-463 |
MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM. |
Selective |
Menin-MLL interaction, IC50: 15.3 nM |
| S7618 |
MI-2 (Menin-MLL Inhibitor) |
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
|
Selective |
Menin-MLL interaction, IC50: 446 nM |
| S7618 |
MI-2 (Menin-MLL Inhibitor) |
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
|
Selective |
Menin-MLL interaction, IC50: 446 nM |
| S7619 |
MI-3 (Menin-MLL Inhibitor) |
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
|
Selective |
Menin-MLL interaction, IC50: 648 nM |
| S7619 |
MI-3 (Menin-MLL Inhibitor) |
MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
|
Selective |
Menin-MLL interaction, IC50: 648 nM |
| S7815 |
MI-136 |
MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
Selective |
|
| S7815 |
MI-136 |
MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes. |
Selective |
|
| S7265 |
MM-102 |
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM. |
Pan |
WDR5, IC50: 2.4 nM |
| S7833 |
OICR-9429 |
OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM. |
Pan |
WDR5, Kd: 93 nM |
| S2184 |
WDR5-0103 |
WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. |
Pan |
WDR5, Kd: 450 nM |
