- PDE1
- PDE2
- PDE3
- PDE4
- PDE5
- PDE6
- PDE10A
- PDE9
- PDE4B
PDE6 抑制剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S5957 | Vardenafil hydrochloride | Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively. | Pan | PDE6, IC50: 11 nM |
| S1431 | Sildenafil Citrate | Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction. | Pan | PDE6, IC50: 33 nM |
| S6433 | Udenafil | Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. | Pan | PDE6, IC50: 53.3 nM |
