| S0531 |
DG172 dihydrochloride |
DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM. |
Selective |
PPARβ/δ, IC50: 27 nM |
| S8020 |
GW0742 |
GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. |
Pan |
PPARδ, EC50: 1 nM |
| S8025 |
GSK3787 |
GSK3787 is a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ. |
Pan |
PPARδ, pIC50: 6.6 |
| S7484 |
FH535 |
FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
|
Pan |
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| S3720 |
Elafibranor |
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. |
Pan |
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