- TLR7
- TLR8
- TLR9
- TLR4
- TLR2
- TLR3
- TLR1
- TLR6
TLR8 选择性抑制剂 | 激活剂 | 激动剂 | 拮抗剂
| 目录号 | 产品名 | 产品描述 | Selective / Pan | IC50 / Ki |
|---|---|---|---|---|
| S9730 | CU-CPT9a | CU-CPT9a is a potent and specific antagonist of Toll-like receptor 8 (TLR8) with IC50 of 0.5 nM. |
Selective | TLR8, IC50: 0.5 nM |
| S4461 | CU-CPT-8m | CU-CPT-8m (CPD1578) is a specific antagonist of toll-like receptor 8(TLR8) with IC50 of 67 nM and Kd of 220 nM. | Selective | TLR8, IC50: 67 nM; TLR8, Ki: 220 nM |
| S7161 | Motolimod (VTX-2337) | Motolimod (VTX-2337) is a selective and potent Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7. Phase 2. | Selective | TLR8, EC50: 100 nM |
| S9937 | CU-CPD107 | CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling. | Selective | TLR8, IC50: 13.7 μM |
| S9931 | Enpatoran Hydrochloride | Enpatoran (M5049) hydrochloride is a potent, orally active, and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM, respectively, in HEK293 cells. | Pan | TLR8, IC50: 24.1 nM |
| S9623 | Telratolimod | Telratolimod (3M-052, MEDI9197) is an agonist of toll-like receptor 7 (TLR-7) and toll-like receptor 8 (TLR-8) with antitumor activity. | Pan | |
| S8133 | Resiquimod (R-848) | Resiquimod (R-848, S28463) is an immune response modifier that acts as a potent TLR 7/TLR 8 agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. Resiquimod reduces hepatitis C virus (HCV) infection. Phase 2. | Pan | |
| S4157 | Chloroquine diphosphate | Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs). | Pan |
